Why Opioids Can Kill and Why Natural Cannabinoids and Cannabis Do Not — Ed Rosenthal

1 Tsou K, Brown S, Sañudo-Peña MC, Mackie K, and Walker JM. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience. 1998 Mar;83(2):393-411. 2 Wang T, Li GQ, Zhang HP, Zhang Y, and Li Q. Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats. J Hypertens. 2017 Mar;35(3):538-545. 3 Zou S, Kumar U. Cannabinoid receptors and the endocannabinoid system: Signaling and function in the central nervous system. Int J Mol Sci. 2018;19(3):833. Published 2018 Mar 13. 4 Glass M, Dragunow M, and Faull RL. Cannabinoid receptors in the human brain: A detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience. 1997 Mar;77(2):299-318. 5 Kwok CH, Devonshire IM, Imraish A, et al. Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. Pain. 2017;158(11):2222–2232. 6 Padley JR, Li Q, Pilowsky PM, and Goodchild AK. Cannabinoid receptor activation in the rostral ventrolateral medulla oblongata evokes cardiorespiratory effects in anaesthetized rats. Br J Pharmacol. 2003;140(2):384–394. 7 Freundt-Revilla J, Kegler K, Baumgärtner W, and Tipold A. Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system. PLoS One. 2017;12(7):e0181064. 8 Thompson, GR, Rosenkrantz, H, Schaeppi, UH, and Braude, MC. 1973. Comparison of acute oral toxicity of cannabinoids in rats, dogs and monkeys. Toxicol Appl Pharmacol 25:363–72. 9 Carter, Gregory T, Patrick Weydt, Muraco Kyashna-Tocha, and Donald Abrams. 2004 (May). Medicinal Cannabis: Rational guidelines for Dosing. IDrugs 7(5):464–70.
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1 Tsou K, Brown S, Sañudo-Peña MC, Mackie K, and Walker JM. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system. Neuroscience. 1998 Mar;83(2):393-411.

2 Wang T, Li GQ, Zhang HP, Zhang Y, and Li Q. Overactivation of cannabinoid receptor type 1 in rostral ventrolateral medulla promotes cardiovascular responses in spontaneously hypertensive rats. J Hypertens. 2017 Mar;35(3):538-545.

3 Zou S, Kumar U. Cannabinoid receptors and the endocannabinoid system: Signaling and function in the central nervous system. Int J Mol Sci. 2018;19(3):833. Published 2018 Mar 13.

4 Glass M, Dragunow M, and Faull RL. Cannabinoid receptors in the human brain: A detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain. Neuroscience. 1997 Mar;77(2):299-318.

5 Kwok CH, Devonshire IM, Imraish A, et al. Age-dependent plasticity in endocannabinoid modulation of pain processing through postnatal development. Pain. 2017;158(11):2222–2232.

6 Padley JR, Li Q, Pilowsky PM, and Goodchild AK. Cannabinoid receptor activation in the rostral ventrolateral medulla oblongata evokes cardiorespiratory effects in anaesthetized rats. Br J Pharmacol. 2003;140(2):384–394.

7 Freundt-Revilla J, Kegler K, Baumgärtner W, and Tipold A. Spatial distribution of cannabinoid receptor type 1 (CB1) in normal canine central and peripheral nervous system. PLoS One. 2017;12(7):e0181064.

8 Thompson, GR, Rosenkrantz, H, Schaeppi, UH, and Braude, MC. 1973. Comparison of acute oral toxicity of cannabinoids in rats, dogs and monkeys. Toxicol Appl Pharmacol 25:363–72.

9 Carter, Gregory T, Patrick Weydt, Muraco Kyashna-Tocha, and Donald Abrams. 2004 (May). Medicinal Cannabis: Rational guidelines for Dosing. IDrugs 7(5):464–70.

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